Related disorders

Symptoms of the following disorders can be similar to those of Asherman’s Syndrome. Comparisons may be useful for a differential diagnosis:

Primary Amenorrhea is the absence or slowing down of menstruation for at least three months. It may be the result of a number of gynecologic problems. Most often this disorder is a result of either too much or too little hypothalamic gonadotropic-releasing hormone (GnRH, a sex cell growth hormone). Symptoms of Primary Amenorrhea may be the absence of secondary sex characteristics, incomplete or underdeveloped external genitalia and breasts, ovarian deficiency, underactive pituitary and an absence of menstruation by age 16. (For more information on this disorder, choose “Primary Amenorrhea” as your search term in the Rare Disease Database.)

In Secondary Amenorrhea, which occurs in Asherman’s Syndrome, the absence of menstruation occurs in women who have previously menstruated. Menstruation ceases following scraping of the uterine wall (D&C) or acute endometritis.

Endometriosis is a prevalent gynecological condition that affects women. It is caused by an inability to shed the buildup of tissue that normally forms in the uterus (endometrium) before menstruation. This build-up of excess tissue can spread as far as the lungs, although it usually accumulates on the bowels or intestines. Symptoms of this disorder may be lower back pain, pain in the thighs or excessive pain during the menstrual cycle. (For more information on this disorder choose “Endometriosis” as your search term in the Rare Disease Database.)

Pelvic Inflammatory Disease (PID) is the infection of the fallopian tubes, cervix, uterus or ovaries. It occurs most often in young women who are sexually active. PID is transmitted by sexual intercourse, childbirth or abortion. The organism Neisseria Gonorrhoeae causes this infection in 40-60% of the patients.

Stein-Leventhal Syndrome is a rare reproductive disorder affecting young women. It is characterized by absent or abnormal menstruation, sterility, mild signs of secondary male sex characteristics, and sometimes obesity. The causes of the syndrome are not understood, but involve faulty production of reproductive hormones. Hormone therapy is often effective, but recurrences are common. (For more information on this disorder choose “Stein-Leventhal” as your search term in the Rare Disease Database.)

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