Asherman’s Syndrome (also known as uterine synechiae) is gynaecologic abnormality which is characterized by the intrauterine adhesions or scar tissues formation in the uterine cavity. As a result, menstrual function disturbance occurs and prevents normal fertilization.
Asherman’s Syndrome can be caused by:
- surgical measures in uterine cervix and salpinges;
- gynecological surgical procedures;
- intrauterine device use;
- infections and bacterial diseases;
- neurosplanchnic disorder (usually after miscarriages).
There are three clinical stages of Asherman’s Syndrome (AS):
- 1st stage – less than 25% of the uterine cavity is damaged, synechiae doesn’t reach fallopian tubes and uterine fundus;
- 2nd stage –from 25% to 75% of the uterine cavity is damaged, there is a partial stenosis of the fallopian tubes and uterine fundus;
- 3rd stage – practically the entire uterus body is involved in the pathological process including uterus adnexa.
Asherman’s Syndrome isn’t an age-related illness thus woman of any age can face with this disease. The most common problem patients with this pathology have is changes in menstrual cycle – it can be lighter periods, or none at all, painful menstrual flow.
Asherman’s Syndrome is serious abnormality which negatively affects female reproductive health. Infertility is the most important complication of Asherman’s Syndrome.
Surgical release of uterine synechiae is the main way of treatment. Even after the surgical interference women who had mild stage of illness have chances for the pregnancy or successful IVF result as well. In the case of advanced disease it’s practically impossible to get pregnant even after operative treatment. Thus surrogacy programs which are listed in the top of ART treatment can help to cope even with the hopeless cases of infertility.